The difference between cloud and mud

The foreign monk Fang Yuanqi won the victory, but the veteran Song Jiaqi capsized in the gutter.

Although the commercial value of btk27 has been emphasized countless times in front of investors, in Jiang Tong's mind, the status of btk27 and cd30 is really different.One is an unprecedented innovative therapy, and the other is a mature product with global sales of billions of dollars—it’s just taking the original drug and modifying a few structures to avoid patent protection. Small investment and high return, the probability of success is infinitely close to 100.

Under such psychological expectations, after hearing the first phase of clinical results reported by Song Jiaqi, Jiang Tong's mood can only be described as shock.

"Why does our btk27 have such strong side effects?" He was more puzzled than angry: "There are two or three similar products in the world, and no researchers have found that this drug can cause hemangiomas in patients in vitro."

"Is patient recruitment going wrong again? Or does the dose need to be adjusted?"

Song Jiaqi stood on the opposite side of the table in a regular manner, without the arrogance on the phone: "We are still investigating the reason... It may be related to the overstimulation of the EGFR signaling pathway."

"But other than that, the primary clinical endpoints of the Phase [-] design were met. The response rate and remission rate exceeded expectations. Hemangiomas currently only occur in vitro and are small in size. To be honest, the actual impact on patients is not great, mainly It's the impression...not very good."

Jiang Tong sighed: "Okay, I accept this statement for the time being. What do you want to do in the second phase of clinical trials?"

"The dose will definitely be adjusted. The first-phase clinical approval for the combination of Btk27 and chemotherapy has also come down, and I will carry out the combined clinical use at the same time to see how hemangiomas are formed after the egfr pathway is inhibited."

Jiang Tong nodded: "That's it. Write a paper on the data of the first phase, and publish it on Asco as originally planned."

Song Jiaqi was a little hesitant: "Should I wait until the second phase or the joint use of the first phase have some eyebrows before going to asco? Let's forget it this time, after all, the result is still flawed..."

Jiang Tong smiled wryly: "Do you think I want to go? It's not because the C round of financing is at a critical moment, and even investors and competitors don't know how many people are staring at the result of btk. We fled without a fight, and everyone will assume that there is a problem with the data .”

"Anyway, the response rate and remission rate in the first phase are good. Although the side effects are a fly in the ointment, they are not fatal flaws." Jiang Tong waved his hand: "Just write the paper well, and don't worry about the rest."

Jiang Tong wasn't trying to comfort Song Jiaqi, but sincerely thought that btk27's mess was within the controllable range.However, the plan could not keep up with the changes. Before asco was held, there was a small incident in the industry.

It's not small, because the protagonist of the incident has a close relationship with both Jiang Tong and Hua Qing.It's not a big deal, because time has passed, and no one in the company cares about him anymore.

Because of falsely reporting invoices and setting up a personal company without declaration, Lu Wei was dismissed by Zhang Yuan in less than a year after joining Yongping.Lu Wei was still on a business trip in Australia on the day he received the email notification. When he returned to China, the research and development department that Lu Wei recruited had changed. Not only did his key card fail, but all his personal belongings were packed and sent home by the secretary.

Jiang Tong learned the news during the team lunch.The whistleblower's wife works in Yongping, and has a lot of first-hand materials that are difficult to distinguish between true and false.

"Everyone in Yongping is spreading rumors that Lu Wei got out because he didn't get along with Zhang Yuan. Zhang Yuan recruited him and originally planned to make him the second in command of R&D, and the salary was good. Who knew that Lu Wei wanted to be the boss. , simply bypassing Zhang Yuan and directly contacting Mr. Zhang, can the 'Eldest Princess' bear it?"

Jiang Tong and Li Qianqian looked at each other, but neither of them spoke.On the contrary, Song Jiaqi frowned and expressed doubts: "From the public documents, Yongping's reason for laying off Lu Wei is very solid. In such a large company, it is impossible to appoint personnel based on Zhang Yuan's likes and dislikes alone."

The person who broke the news shrugged: "I don't know. Anyway, Zhang Yuan must be unhappy with Lu Wei. I heard from my wife that Zhang Yuan signed and fired Lu Wei. He didn't even call him, so he took advantage of Lu Wei in Australia. I sent an email when I was on the flight. After getting off the plane, Lu Wei read the email and immediately returned home, but he didn’t even go through the gate of Yongping.

The phone vibrated, and he opened it, his eyes lit up: "Look, this is a photo taken by her colleague in the building. Even though it's a little far away, you can still see people clearly."

The mobile phone uploaded a circle around the dining table, and everyone was amazed.Jiang Tong looked at the photo with mixed emotions, although the pixels were a little blurred and the figure was a little smaller.The person pulling together with the security guard in a funny pose is indeed Lu Wei himself.

"Sluts have their own money." Li Qianqian enjoyed watching it: "Send me this picture later, I want to treasure it forever."

After this battle, Lu Wei was kicked out by Yongping Minghuang, and he was labeled as an enemy of Zhang Yuan. Although he is not far away from everyone in the industry, he is not far away.Jiang Tong sighed in his heart for a moment and forgot about it, but received a call from Lu Wei that night.Seeing the number on the screen, he originally wanted to hang up directly, thinking about the situation with everyone, Lu Wei is in trouble now, he has already stood by on the shore, so there is no need to step on it and make it worse.

Jiang Tong thought in his heart that he would stay on the front line in everything, and be a good person to meet and answer the phone, but found that he thought too much about Lu Wei.

"You did it." Lu Wei's voice was weird, higher and sharper than usual, with a strange excitement: "I knew it, it must be you."

Jiang Tong was baffled, and before he could speak, Lu Wei's cursing on the other end of the phone was like machine gun fire.

"That bitch Zhang Yuan still doesn't admit it, but I found it out! Jiang Tong, do you think that killing me will make Huaqing cash out without any worries? Go and live your tm big dream!"

"If I hadn't dragged you out of the laboratory back then, how would you be where you are today? That's right, I'm in trouble now, your grandfather's emaciated camel is bigger than a horse! I'm going to tear you apart, and I have to pull you off the horse too!"

"I'll let you be proud for a few days first, and there will be times when you cry and beg me in the future. Prepare me mentally!"

Before Jiang Tong could organize his words, Lu Wei hung up the phone with a bang—after hearing the abnormal loud noise at the end, he might even throw the phone against the wall.

Inexplicably being threatened and abused, Jiang Tong didn't get angry, but felt that Lu Wei was pitiful.The first time he met Lu Wei, the other party was wearing a non-pleated suit, full of momentum, talking about business, and others didn't even have a chance to intervene.Even when the two parted ways in the end and the trouble was the worst, Lu Wei would always put on a mature and rational face, making Jiang Tong look like an adolescent high school student against him.

A gaffe like today is simply a fantasy for Lu Wei who was half a year ago, no, a month ago.It seems that he has really reached a desperate situation.

He can't even save himself, so what leverage can he have against Hua Qing and Jiang Tong?

Jiang Tong sneered, and deleted Lu Wei's phone number from the phone's address book.

Sure enough, Lu Wei had nothing to say after his harsh words, and Jiang Tong gradually forgot about him.It was only on the way to the United States to participate in asco that Jiang Tong and Xiao Fengtai, who was looking for new projects with his colleagues, did not feel bored, so they brought up Lu Wei as a topic of conversation again.

Contrary to Jiang Tong's expectation, Xiao Fengtai became seriously worried for Huaqing after hearing him tell the whole story.

"You told Song Jiaqi and the others to be careful recently." He said with a serious face, "I don't think this is over yet."

Jiang Tong said it was difficult to understand: "Lu Wei Du Ni Bodhisattva crossing the river is hard to protect himself, and he can still be distracted to deal with Huaqing? It means that he is in a bad mood and finds someone to vent. I am worried that he will not be able to bear the blow and have mental problems. "

Xiao Fengtai said: "That's why you need to pay more attention. Once a lunatic gets sick, he neither speaks logic nor cares about the consequences."

"Your inference about Lu Wei is based on your previous experience with him. At that time, Lu Wei had too many scruples, and he had to pay attention to demeanor and propriety. Now he is barefoot and not afraid to wear shoes, and he only thinks that you ruined his career. I want to fight you to the death. If he really gets caught, even if he can't bring down Huaqing, it will still be enough for you to drink a pot."

Jiang Tong didn't take it seriously, and Xiao Fengtai saw that he didn't get into it, so he wisely stopped mentioning it.However, when they landed in San Francisco, when the two turned on their mobile phones to check the information, they were shocked to find that Xiao Fengtai's words came true, and Lu Wei, as the former vice president of Huaqing, publicly declared that there were major flaws in the structural design of btk27.He even disclosed the phase I clinical data of btk27 in advance, citing the widespread occurrence of in vitro hemangiomas in the tested patient population as evidence.

The lead investor and follow-up investors of the C round of financing have already been basically finalized. Not only the potential investors, but also the ab round investors who have already boarded the ship have been blown up.Jiang Tong kept answering the phone from the airport to the hotel until the phone turned off automatically due to low battery.Xiao Fengtai watched coldly, without saying a word.

"Do you have a power bank?" Jiang Tong said anxiously to Xiao Fengtai: "Lend me to use it, I just talked about the key point."

"Give me the phone." Xiao Fengtai was noncommittal.

Jiang Tong was confused and did as he said: "What do you want to do? Just give me the power bank, and I will plug it in myself."

"Who told you that I have a power bank?" Xiao Fengtai put the phone in his pocket and gave him a strange look: "Even if I had it, I wouldn't give it to you."

"Enough calls tonight. I think you only have three things to do until eight o'clock tomorrow morning."

He raised his finger: "One, take a good shower at the hotel; two, order dinner with a glass of good red wine; three, calm down and think about what to do next, and then go to bed."

"You should especially calmly consider whether to attend tomorrow's seminar as originally planned. Lu Wei deliberately released the news before asco, hoping to catch you off guard. Especially considering that the C round of financing is coming soon, I don't recommend you Disclose the progress of btk research and development by yourself in the case of communication with shareholders and investor relations team.”

Jiang Tong didn't speak for a few minutes.Arguments came to his lips, but he stopped for no reason.

"In what capacity are you making suggestions to me?" He stared at Xiao Fengtai: "Peer, friend, or shareholder?"

Xiao Fengtai avoided his gaze: "It's not important."

Jiang Tong smiled, unable to see emotion: "As the founder and chief scientist of Huaqing, I guarantee with my academic life that the side effects of btk27 are within the controllable range. Yes, the structure of btk is different from the original research, but it is absolutely Not a defect. In fact, the results of the phase [-] trial data are generally very good, and we have also done a preliminary analysis of the mechanism of side effects. I believe that in the case of adjusting the dose and combining chemotherapy drugs, the probability of hemangioma will be greatly reduced .”

"In short, Hua Yu can't lose money." He stretched out his hand to Xiao Fengtai, palm up: "Please return the phone to me."

"That was not what I meant……"

Jiang Tong kept his posture unchanged: "Unless Hua Yu requests a shareholders' meeting and obtains a majority of shareholders' votes, he cannot intervene in the company's major business decisions. Please give me your mobile phone. I need to contact my colleagues in the company to adjust tomorrow's ppt and speech. "

Xiao Fengtai had no choice but to take out the phone and return it to Jiang Tong.

"You misunderstood." He hesitated to speak: "I...I want to say..."

He suddenly felt a little dazed, a little timid, Jiang Tong's question, he had an answer in his heart.However, this answer is not in Jiang Tong's preset options.

Jiang Tong couldn't see his struggle.

"I'm going back to my room first." He gave him a calm back: "See you tomorrow."