Enteric typhoid fever is an acute infectious disease caused by Salmonella typhi.

Infects humans via the fecal-oral route.If the water source is contaminated by feces containing typhoid bacilli, it will cause an explosive epidemic in the area.

It is also commonly known as the "plague".

"Immediately seal Shangdang County and no one is allowed to enter or exit! All infected people will be quarantined immediately!"

Mu Tingxue issued a strict order, "Everyone in Baidi Prefecture must immediately disinfect the toilets with lime again. It is forbidden to drink raw water and avoid eating undercooked meat and unpeeled fruits."

She immediately transferred two thousand tons of lime from the lime factory and asked the army to transport it to Shangdang County for a major disinfection.

The most important thing to control enteric typhoid is to control the source of infection and cut off the transmission route.

In particular, water source management, food management, feces management, and fly elimination need to be done well.

"This is not enough, I have to go back and buy medicine quickly!"

After Mu Tingxue finished explaining, she immediately traveled back to modern times.

Contact an old acquaintance of the medical representative.

"Boss Mu, what medicine do you need this time? Last time you ordered [-] bottles of Huoxiang Zhengqi water here, and the sales were pretty good."

"It's selling very well. Please help me get a batch of third-generation quinolones, including norofloxacin, levofloxacin, ofloxacin, and ciprofloxacin. One hundred thousand... 50 Wanhe!"

There are 10 people in Baidi Prefecture. The enteric typhoid fever spread from nearby Huaizhou. It can be seen that Huaizhou has fallen, and several nearby states and counties have also spread.

"Boss Mu, this may be a bit difficult to handle. The quantity you want is too much. The factory does not have that many quinolones at the moment."

"It doesn't need to be in boxes, it can be in bulk or in tablets." Mu Tingxue said in an urgent tone.

"Pharmaceutical factories can only get about 20 yuan." Medical representative Long Ge gave an accurate figure. "If we transfer goods from other factories, we can only get 30 yuan at most."

Mu Tingxue calmed down and thought about it.

Ancient people never took antibiotics. The typhoid bacilli they were infected with had no resistance at all. There was no need to stick to the highly resistant third-generation quinolones. Just use the first-generation chloramphenicol!

What more high-end antibiotics are needed?

Since 1948, chloramphenicol has been used to treat enteric typhoid fever for more than 50 years and was once the most effective drug of choice.Later, people used it more often, and typhoid bacilli evolved resistance to chloramphenicol, so it gradually became ineffective.

Enteric typhoid plague broke out in Huaizhou. It must be the most primitive strain of typhoid bacilli, and it can be easily cured with the cheapest chloramphenicol!

"Where are the chloramphenicol tablets? How much is left in stock? I want them all."

"There are about [-] boxes of finished films. But——"

"But what?"

"There are still ten tons of chloramphenicol crystalline pharmaceutical raw materials that have not yet been processed. They are all CDE registered, pharmaceutical grade, and have not yet been processed into tablets or capsules."

"I want this!" Mu Tingxue secretly rejoiced and wrapped up the ten tons of chloramphenicol raw materials.

What kind of processing and packaging is required?One tablet contains 0.25 g.

Adults should take 1.5 to 3 grams of medicine a day, divided into 3 to 4 times. Just give these active ingredients directly to plague patients according to the corresponding grams.

"I'll give you a discount, 80 yuan per kilogram."

Mu Tingxue didn't even bargain, and the 80 RMB was spent.

A normal 250g bottle of chloramphenicol tablets costs about 30 yuan in her store.The purchase price is more than ten yuan.

After buying the medicine, she added some mustard, Jiangxue, and red wine.

During the two hours she waited for ten tons of chloramphenicol to arrive, she went to the bookstore on the east end of the street and bought a few books, mainly about cement and civil engineering.

When I came out of the bookstore, I happened to see two road rollers and drove past them.

There is a small road on the east side. The road is being built and the foundation is being laid. Clay and sandy soil are alternately laid in layers. Then a single person drives a road roller to run over it and compact the foundation.The working weight of the roller is marked as 8 tons.In just a short time, a hundred meters of roadbed was flattened and solid.

In ancient times, stones were used to pave roads.

A bit like a country rock roll, but much bigger.

When Qin Shihuang built the Qin Straight Road, the largest Shiluqi was unearthed, weighing 1.2 kilograms, or three tons, and about [-] meters in diameter.It is pulled by manpower or animal power and pressed against the road, so the speed is relatively slow.

Mu Tingxue opened the wholesale website and searched for small rollers, and found that the sales volume was very high: "There are hand-push types and ride-on types, with working weights of 1-8 tons. They can press foundations, lawns, and gully backfills."

The size is quite compact.Requires fuel consumption.

It is a high-tech product, mechanized construction.To build roads in Yunhuang, migrant workers still need to dig shovelfuls of soil and carry clay one shoulder at a time.

"If this small roller were taken out, it would probably cause huge panic among the indigenous people."

After thinking twice, Mu Tingxue suppressed the idea of ​​purchasing.

She contacted the mask factory and bought [-] masks.

Returning to the pharmacy, I delivered ten tons of medical chloramphenicol raw materials to the medical representative and paid for the delivery.

Not daring to delay, she immediately returned to Baidizhou.Distribute masks to government officials and soldiers ordered to spread lime for disinfection.

"what is this?"

Huang Zhu took the medical mask and rubbed it with his hands, "It actually has three layers of fabric, a style I have never seen before."

Mu Tingxue personally demonstrated: "Wearing it on your face like this can prevent you from inhaling harmful dust. Inhaling quicklime into your nose is not good. It can also prevent the plague from being transmitted through the mouth and nose."

Typhoid bacilli are not transmitted through the respiratory tract, but can be transmitted orally. Masks are still useful.

Huang Zhu immediately received [-] masks: "I will distribute them to the soldiers right away."

Mu Tingxue also set off.

"Your Highness, please don't go out. It's dangerous outside. If someone accidentally gets infected, it will be bad." Huang Zhu stopped her.

"I'm going to Shangdang County to distribute special medicines to patients."

"Is there a specific medicine for enteric typhoid fever?"

Huangzhu was deeply shocked. In just a few days, from the outbreak of this plague to Huaizhou, doctors said there was no cure. The patient continued to have high fever, some diarrhea and intestinal bleeding, apathetic expression, and even coma. As a result, Her Royal Highness the Princess They actually said it can be cured!

This was a great morale booster.

The availability of special medicine means that enteric typhoid fever will not break out wildly and Baidi Prefecture will not become a dead city!

"Of course, let's go. Time is life."

Mu Tingxue got on the carriage.

Baidi Prefecture Government Office is located in Shangdang County and can be reached in just two quarters of an hour.

Confirmed typhoid patients were isolated in rows of adobe houses.The area around the house has been plastered and pest control and sterilization treatments have been carried out.

Wearing a mask and gloves, she came in to check in person.

"Your Highness, it is absolutely impossible!"

A local old country doctor was horrified when he saw this. He stepped forward to stop him and said, "How could you set foot in such a filthy place, what if you are so wealthy? What if you were infected..."

"It's okay, nothing will happen."

Mu Tingxue personally brought in a box of chloramphenicol.

In this isolation house, there is a family of six, a couple and three children.

The thermometer measured them and they were all between 39-40 degrees. The couple's symptoms were the most severe and they were in a coma due to high fever.Ignoring the old doctor's obstruction, she insisted on tearing off the ten-year-old boy's shirt: "There are dozens of light red papules and rashes on the chest, abdomen, shoulders and back."

The old village doctor said: "This is heat poison."

Mu Tingxue said: "This is roseola, one of the main clinical manifestations of enteric typhoid fever. It fades under pressure."

It's not big, 2-4 mm.

Then he palpated the patient's liver and spleen with his fingers: "Obvious hepatosplenomegaly."

She took about a gram of chloramphenicol, poured it into warm water, and gave it to the three children. The dosage should not be too strong for children.

The adults drank one gram and one cup.

"Take medicine three times a day." Mu Tingxue ordered, "Give special medicine to all infected people in Shangdang County!"

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