my life simulator

"The successful development of this technology marks that my country has reached the world's leading level in high-precision processing technology!"

As soon as the news came out, domestic reactions were mediocre.

Professor Lu is leading the world again.Well, this is the basic operation.

There was an uproar abroad.

Fuck!The high-precision processing technology of the florist has actually achieved an error of no more than one micron?

We are still struggling in the ten micron range, how the hell are you down to one micron?

And...that Professor Lu again?

You are a genetic scientist, what kind of high-precision processing technology are you studying?It's not doing business properly, you know?

Chapter 537 The terminal illness that plagues human beings is missing one more

High-precision laser processing technology has achieved success.

Aside from those major strategic significance, purely in robotics, the bottleneck of the reducer no longer exists.

Next, Lu Li plans to overcome another difficulty - the servo motor.

However... things are unpredictable.

Just as Lu Li was about to devote himself to the research of servo motors, he got a piece of news by accident, which forced Lu Li to change his research direction.

In the evening, Lu Li returned to Fudan's dormitory and had dinner with Liu Qin.

"Lu Li, do you still remember Wang Yan?"

Liu Qin picked up a chopstick dish for Lu Li, and looked up at Lu Li.

"Wang Yan?"

Lu Li thought for a while, and with his strong memory, Lu Li immediately searched for the past memories from the depths of his memory.

Wang Yan, Lu Li's high school classmate.

When she was in Yucheng No. [-] Middle School, Wang Yan was Liu Qin's deskmate.

"Wang Yan, old classmate!"

Lu Li smiled, and said to Liu Qin, "Back then, when I was in Yucheng No. [-] Middle School, Wang Yan was at the same table as you! Why, you suddenly mentioned Wang Yan today?"

"Wang Yan..."

Liu Qin sighed, "She's sick, terminally ill! This morning, she called me and was crying. I felt very uncomfortable when I heard it."

"Ill? What kind of illness?"

Lu Li put down his chopsticks and asked Liu Qin.

"AIDS!"

Liu Qin sighed and shook his head, "She found a boyfriend, but..."

"So it is."

Lu Li also sighed, and said to Liu Qin, "Wang Yan called you to ask me for help, right?"

It's not hard to guess.

Lu Li is the top genetic scientist in the world today, and has also made major scientific achievements in overcoming cancer in the medical field.

If there is anyone who can overcome AIDS, perhaps only Lu Li can do it.

When Wang Yan found Liu Qin, she wanted to ask Lu Li for help, which was only natural.

"Wang Yan definitely meant to ask you for help."

Liu Qin nodded, and said to Lu Li, "Lu Li, Wang Yan... is so pitiful, if you can help, please help her! Besides, conquering AIDS is also a major scientific achievement!"

"You have so much confidence in me?"

Lu Li laughed, "AIDS, this is one of the five deadly diseases in the world. Do you think I can find a cure for AIDS in a short time?"

"I must have confidence in you!"

A smile appeared on Liu Qin's face, "You are the top genetic scientist in the world. If you can't do it, then no one can."

"Haha! I love hearing that!"

Lu Li laughed, "Okay! I'll put the project in hand and turn to research on the treatment plan for AIDS!"

"Thank you! I thank you for Wang Yan!"

Liu Qin was so happy that he quickly took out his phone and called Wang Yan.After the call was connected, Liu Qin said to Wang Yan, "Wang Yan, I told Lu Li. He will find a way to help you."

"Thank you!" On the phone, Wang Yan broke down in tears.

……

The next day, Lu Li came to the laboratory of Fudan Medical College again.

In the laboratory, Wen Wanmei and other graduate students are still working on the human genetic testing project, and the results are not far away.

Lu Li didn't bother them either. He turned around and went to another laboratory to study HIV.

HIV, which is a retrovirus, mainly invades T cells in the human immune system, thereby destroying the human immune system.

This is a typical virus invasion mode.

HIV invades T cells, and then transcribes and replicates in T cells to generate countless HIV, which spreads in a large area, kills T cells in a large area, and completely destroys the human immune system.

At present, according to the WHO report, there are nearly 4000 million AIDS patients in the world, 270 million new infections are added every year, 200 million people die of AIDS every year, and tens of thousands of people are infected with AIDS every day on average.

In my country, there are nearly one million AIDS patients, covering all provinces, municipalities and autonomous regions of the country.

AIDS is very dangerous.So far, there is still no real cure.

This time, because of Wang Yan's matter, Lu Li devoted his mind to the research of AIDS treatment.

In fact, this is not only for Wang Yan, but also a major scientific research that benefits the whole world.

in the laboratory.

Lu Li sat in front of the test bench, carefully observing the process of HIV invading T cells through an electron microscope.

On the display, HIV invades the nucleus and decomposes into RNA gene transcription information.

Immediately, this HIV gene transcription information was quickly combined with the DNA molecular chains in T cells.The gene transcription mechanism is deceived, so that the DNA transcription mechanism generates HIV DNA molecules according to the transcription information.

Non-stop transcription, non-stop generation of HIV DNA molecules.Until the entire T cell is full of HIV.

By this time, the T cells have died and all nutrients have been used to make HIV.

Next, tens of thousands of HIV seeped out from the dead T cells, spread continuously, and crazily invaded other T cells.

This is how HIV works.

In fact, the infection mechanism of all viruses is exactly the same as this one. It combines the genetic information of the virus with the DNA of the cell, continuously replicates, continuously generates new viruses, and continuously invades other cells.

Lu Li has already done in-depth research on T cells.

When he was researching cancer treatments, the CAR-T anti-cancer technology developed by Lu Li used the immune function of T cells to kill cancer cells.

Now, when it comes to AIDS, the weapon Lu Li used at the beginning has become the target of the virus.

To treat AIDS, Lu Li still started from genetics.

All HIV treatment options in the world today are unsuccessful, at least not curative.

Lu Li had already thought of a genetic solution to HIV, and it was a method that already existed in nature.

In nature, a war that has lasted for hundreds of millions of years is breaking out all the time, right around us.

This is the war between bacteria and viruses.

The virus invading bacteria is no different from invading human cells. It also combines the gene transcription information of the virus with the DNA molecules of the bacteria, different transcriptions, and non-stop replication.

In the hundreds of millions of years of war between viruses and bacteria, bacteria have evolved a defense mechanism in order to fight against viruses.

This gene sequence called "CRISPR" is a repetitive sequence in the genome of prokaryotic organisms, and it is an immune weapon produced by the struggle between bacteria and viruses in the history of life evolution.

Simply put, bacteria have evolved the CRISPR-Cas9 system in order to clear the foreign invasion genes of viruses.Using this system, bacteria can quietly remove the virus gene from their own genome, which is a unique immune system of bacteria.

In fact, the gene editing technology in the world today is the gene cutting technology developed based on this CRISPR-Cas9 system.

Now, Lu Li's idea is to use the CRISPR-Cas9 system to arm T cells.

Once HIV invades T cells, the genetic information of HIV will be cut off by the CRISPR-Cas9 system, thereby preventing HIV infection.

If successful, the technique could lead to a vaccine against HIV infection.

Of course, for patients who are already HIV-infected, the technology will still be therapeutically effective enough.

T cells in the human immune system can continuously replicate and proliferate.If all the newly born T cells have the ability to fight against HIV, then... Even if HIV kills all the original T cells, it will not be able to invade the newly born T cells.

This way, HIV cannot destroy the body's immune system.The remaining HIV will also be cut off by the CRISPR-Cas9 system because the virus keeps invading new T cells, and eventually all die.

In theory, this idea is achievable.

Now let's see if we can successfully complete the experiment and equip this CRISPR-Cas9 system into T cells.

"Open the virtual lab!"

With a thought, Lu Li directly opened the virtual laboratory, ready to do research in the virtual laboratory.

"A virtual AIDS patient."

Lu Li was going to do human genetic experiments directly.This kind of experiment is difficult to do in reality, but it is very convenient to do it in a virtual laboratory.

After imagining an AIDS patient, Lu Li picked up the syringe and took out a hematopoietic stem cell sample from the patient's spinal cord.

T cells in the human immune system are transformed from hematopoietic stem cells induced by thymus hormones.

The research that Lu Li is going to do now is to equip the CRISPR-Cas9 system when hematopoietic stem cells transform into T cells, so that the newly generated T cells can have cellular immune function.

It is not difficult to equip cells with the CRISPR-Cas9 system.

When doing gene editing, it is necessary to inject CRISPR-Cas9 cutting protein into the cells to be cut and edited.

The real difficulty lies in how to make the hematopoietic stem cells produced in the spinal cord automatically generate immune T cells according to the new template during the process of converting them into T cells.

This involves RNA gene transcription information again.

Lu Li also had to express the armed T cell genes in the form of RNA gene transcription information, so that the hematopoietic stem cells could replicate according to this new template.

Fortunately, with Lu Li's current knowledge of genetics, it is not difficult to do this.

Next, Lu Li extracted the gene information target of AIDS, added it to the gene target of the CRISPR-Cas9 cutting protein, and then injected it into T cells, combined with the T cell DNA molecular chain, and then injected transcriptase to generate new Gene transcription information.

The newly generated gene transcription information is extracted, injected into hematopoietic stem cells, and combined with the DNA molecular chains of hematopoietic stem cells.

Then... In the hematopoietic stem cells, according to the new gene transcription information, new DNA molecular chains are generated to generate new immune T cells.

At this point, 90% of the experimental process has been completed, and the next step is to see the real therapeutic effect.

Lu Li cultivated the prepared hematopoietic stem cells into hundreds of millions, reinjected them into the patient's body, and transformed them into new armed T cells through the thymus.

After waiting for a few hours, Lu Li took lymph fluid from the patient for testing.

It turns out that... newly generated T cells with the CRISPR-Cas9 system have emerged in large numbers.

In these T cells equipped with the CRISPR-Cas9 system, all the genetic information of the virus invaded by HIV is targeted by the target information of the CRISPR-Cas9 system, directly shortening the genetic information of HIV, and successfully killing an HIV.

The immune system is still constantly generating new T cells. These new T cells are all new T cells equipped with the CRISPR-Cas9 system, and all of them can kill the invading HIV.

After the T cells in the patient's body have been replaced for a round, once HIV invades the new T cells, they will be wiped out one by one, and finally disappear completely.

This process... lasts about one to three months, and the HIV virus will be completely killed within half a year at the longest.

Of course, before the complete cure, the HIV in these patients is still highly contagious.

It took two weeks in reality and more than four months in the virtual laboratory.This virtual AIDS patient was completely cured.

Lu Li conducted a detailed test on this virtual patient, and there was no HIV in the patient's body.

The experiment was successful!

Next, Lu Li repeated the genetic experiment in reality.Human experiments can't be done in reality yet.

After repeating the genetic experiment in reality, the following time is the time to write a thesis to pretend.