my life simulator

Same this time.

Lu Li directly injected the modified B cells into the experimental human body.

And then... nothing happened.

Um?how come?

Lu Li was taken aback, and quickly picked up the testing equipment to carefully examine the experimental body.

Then, Lu Li found out the reason!

B cells that block the ability to receive information are also a "quiet handsome man"!

Not receiving any information, it returns to the lymph nodes along with the lymph fluid, and stays there motionless, leisurely.

On the contrary, it is the other B cells that exist in the human body. After receiving the information, they copy crazily, release immune factors crazily, and trigger the immune system to go crazy.

So... B cell "shutdown" is also not acceptable!

What the hell should we do?

Lu Li's head hurts a bit!

Forget it, take a break first.For more than a month, I have been doing research at home every day, and my people are getting rusty!

After closing the virtual laboratory, Lu Li got up and went out, and started running around the artificial lake in Binjiang Garden!

While running, Lu Li suddenly saw a girl in front of him doing morning exercises.

This girl is wearing a white tight-fitting sportswear, and her figure...is really bulging.

Fortunately, Lu Li's will was as firm as steel, even when he saw such a provocative scene, his heart didn't fluctuate.

Even thinking about it...the chest and hips are too heavy, which affects the body's movement coordination.This kind of body structure does not conform to the laws of nature. In the cruel natural competition, it will definitely be eliminated by natural selection!

The next moment, Lu Li thought again...Humans no longer need to endure cruel natural selection!This body structure is more suitable for gene transmission.

So, what is going on in the mind of the scientific research dog?

Just as Lu Li was thinking about serious scientific issues, the girl with a sultry figure heard footsteps behind her and turned her head to look over.

Seeing Lu Li's handsome face, slender figure, and strong muscles, a light flashed in the girl's eyes, and a smile appeared on her face.

"Hi!"

The girl waved to Lu Li, and took the initiative to say hello.

Uh... Because of my handsome appearance and strong figure, I am very suitable as a combination of genetic transmission, so, under the control of genetic instinct, she took the initiative to greet me.

Sure enough, human beings are just tools dominated by genes!

Love is just the instinct of gene transmission, family affection is just the instinct of protecting the continuation of genes, and human beings are just tools dominated by genes.

A series of scientific explanations popped up in his mind, but Lu Li responded with a smile, "Hi!"

Nothing else, the main thing is... too big!

It's still genetic!

"Do you live here too? Why haven't I seen you before?"

The girl slowed down and ran side by side with Lu Li.

"I've lived here for more than a year."

Lu Li replied, and then asked, "Do you live here too? I haven't seen you before!"

"Just arrived a few days ago!"

The girl smiled, "I used to be in the capital. My sister lives here. I'm here to see my sister!"

"Oh! The capital city is a good place!"

Lu Li nodded, "I also stayed in the capital for a while before."

That's in the plot.In the actor's plot and the master craftsman's plot, Lu Li spent a long time in the capital.

"is it?"

While the girl was running, sweat permeated slightly on her fair face, and she actually had a strange beauty like rolling balls on a jade plate.

"My name is Wen Wan, how about you?"

The girl introduced herself, then turned to Lu Li and asked.

"My name is Lu Li."

"Land from?"

Before Lu Li could finish speaking, the Wen Wan girl exclaimed, "You are the Lu Li who developed the CAR-T technology? Oh my god! I didn't expect to meet you here, what a coincidence!"

"My popularity isn't that high, is it?"

In today's society, people only pay attention to celebrity gossip, who cares about scientific research dogs?

"Let me introduce myself. Wen Wan, a graduate student in basic medicine from Union Medical College."

Wen Wan smiled at Lu Li, "Boss, don't you know how famous you are? You are our idol!"

"Oh! So it's my colleague!"

Lu Li nodded, "No wonder you know me."

"Boss, add a WeChat account!"

The gentle girl took out her mobile phone from her sports wrist bag and shook it at Lu Li.

"WeChat?"

Lu Li paused, and a flash of inspiration flashed in his mind.

Yes!WeChat!

My previous thinking was wrong!

Why shut down B cells?Why make B cells unable to receive information?I just need to prevent B cells from sending "WeChat" and "Moments"!

B cells receive the information from dendritic cells, immediately activate the stress mechanism, and continue to divide and proliferate.

Then... After these genetic modifications, the B cells that "can't send WeChat" and "can't post to Moments" have seized the positions of other normal B cells on a large scale, and then "the corpse meal", what not to do!

In this way, the chance of immune factor outbreaks will be greatly reduced!

"Hahahaha!"

Lu Li laughed loudly, turned around and ran away, and disappeared without a trace.

Behind him, the Wen Wan girl's face was dull!

what does it mean?I asked you for a WeChat, is it so funny?

Also, what do you mean by running away so quickly?

Are all scientific research dogs such straight steel men?You deserve it!

The Wen Wan girl stomped her feet heavily, with a gloomy look on her face!

……

Lu Li suddenly realized that he had found a breakthrough, so why would he care about any girls?

After running home in a hurry, Lu Li lay down on the sofa regardless of the sweat on his body, closed his eyes, and opened the virtual laboratory again.

"A virtual experimental human body with terminal cancer!"

When they came to the virtual laboratory, Lu Li ordered directly, then hurriedly changed into a white coat, and walked into the operating room.

After taking the specimens from the experimental human body, picking up several specimens including cancer cells, T cells, and B cells, Lu Li hurriedly sat down in front of the test bench and continued the experiment.

Car-T experiments were done first to prepare the required T cells, and then Lu Li took out the B cell samples and began to genetically modify the B cells.

The direction was right, and the experiment went smoothly.

Lu Li used splicing proteins to modify the genes of B cells, blocking the ability of B cells to transmit information to the outside world.

Then... Lu Li picked up this B cell and injected it into the experimental human body.Using CAR-T technology, the gene-edited T cells were also injected.

The next moment... a miracle was born!

The "hostile sequence" of T cells discovered the cancer cells in the experimental human body, immediately stimulated the immune mechanism, crazily divided and proliferated, and launched a violent attack on the cancer cells.

At this time, the T cell army was dispatched, and the "intelligence agent" dendritic cells were aware of it, and quickly sent information to the B cells, kept calling for reinforcements, and kept reporting the news of the "war outbreak".

Normal B cells are activated and immediately divide and proliferate.However... the B cells whose genes had been modified by Lu Li were also proliferating violently.

In this way, many "corpse-position vegetarian" B cells occupy logistics and command positions.Their inaction has significantly slowed down the immune mechanism.

The "immune factor storm" did not break out on a large scale, nor did it cause the immune system to go crazy on a large scale.

Although the experimental body still had a fever and the immune response was still intense, the immune system did not attack vital organs indiscriminately, and did not cause heart failure, lung failure, and other internal organ failure.

The experiment was a success!

Lu Li laughed out loud.

This sense of exhilaration in overcoming a difficult scientific research problem and the sense of accomplishment in a technological breakthrough made Lu Xin very happy!

From a certain point of view, CAR-T technology already has clinical value!

It reduces the immune response, avoids the storm of immune factors, and avoids the indiscriminate attack of the immune system on the human body, but can accurately kill cancer cells. This is the best way to treat cancer.

It's just...it's still not a complete cure.

Once T cells kill cancer cells in the body, they self-destruct and do not persist in the body for long.

And then... after a while, maybe three years, maybe five years, maybe ten years, the cancer cells will reappear.

For those who have had cancer, the genes of cancer cells are imprinted in their DNA, and relapse is inevitable!

Of course, after relapse, CAR-T technology can still be used for treatment!

However, this again presents a new problem.In the battle against T cells, cancer cells are likely to have new mutations, and they may have the ability to resist T cell attacks.

Just as viruses mutate constantly, it is almost inevitable that cancer cells will evolve and mutate.

So... Although Lu Li has figured out the best treatment method against cancer, he still hasn't conquered cancer fundamentally!

Lu Li was still not satisfied with his research results.

……

After closing the virtual laboratory, Lu Li took a shower, changed his clothes, sat down at the computer desk, and began to write his thesis.

"Application of gene editing technology for T cells and B cells in CAR-T technology."

Lu Li proposed a brand-new theory. On the basis of modifying the T cell's "identification system" and "calling friendly forces", he further proposed a plan to shield the B cell's command ability.

This is a mature technology that is ready for clinical application.

Papers are open to the world.In this paper, Lu Li only described it theoretically, and did not express the experimental data and specific operation methods.

Immature technologies can be made public.Mature technology must be kept secret.

After writing this purely theoretical paper, Lu Li wrote a detailed experiment report, which clearly stated the experimental data and experimental procedures.

Lu Li is going to hand over this experimental report to Fudan Medical College. As for how the higher-ups plan to deal with this scientific research result, that is something that the leaders will consider!

After writing out the thesis and the experiment report, Lu Li passed the test on a USB flash drive and hurried to Fudan Medical College.

"Little Lu, are you here?"

Seeing Lu Li coming, Professor He greeted him with a smile, "Are you... submitting your graduation thesis?"

"Ok!"

Lu Li nodded, "Teacher, I wrote a thesis, and it's about CAR-T technology. Take a look."

With that said, Lu Li took out the USB flash drive and copied the thesis and experiment report into Professor He's computer.

"I have to take a good look at your graduation thesis!"

Professor He reached for the mouse and clicked on Lu Li's paper.

"Application of gene editing technology for T cells and B cells in CAR-T technology?"

Seeing this title, Professor He was shocked, turned to look at Lu Li, and asked repeatedly: "Application? You said application? Are you sure?"

Applying this word is not easy to write.Dare to say "application", that is a mature technology!