top student at medical school

"When did he go in? How did he get in? Why did he drive in?" Professor Zhang Quan's voice and expression were completely distorted.

After arguing with Du Xinzhan for a while, when he regained his normal thinking, he found that Fang Ziye had already opened the spinal canal of the rabbit, which was lying on its back, and had also cut open the dura mater and arachnoid mater outside the spinal cord!

However, even Professor Zhang Quan, who is considered an expert in Hubei Province and even nationwide, found that he could only understand the scene of the spinal cord being opened.

The actions Fang Ziye is currently taking have entered his blind spot in thinking.

More importantly, he also lost the first glimpse of Fang Ziye opening the spinal cord, which meant he had no chance to deduce Fang Ziye's intentions even if he wanted to do so.

Du Xinzhan smoothed the slightly wrinkled corners of his isolation suit: "At such a crucial time, do I really need to remind you specifically when to go in?"

"Professor Zhang, you clearly knew the key to the operation, yet you still wanted to fight me. Where were you before?"

Zhang Quan didn't turn around this time. With his hands behind his back, he was already in a meditative state after he finished speaking!
Impulsiveness leads to mistakes, and he has already missed the first opportunity to resolve the matter. He is no longer willing to engage in a war of words with Du Xinzhan.

Du Xinzhan, a mere child, what did he know about the spinal cord?
He doesn't understand the true value of this surgery or treatment for this disease at all. Even if you win an argument with him, you'll miss out on the subsequent witnessing, and you'll have lost big time.

Fang Ziye had not given any explanation before the operation, so it was even less likely that he would stop his operation to explain the surgical plan.

This is an animal experiment. After the operation is completed, there will be plenty of time for surgical debriefing. At that time, the theory and ideas will be explained in detail based on the surgical procedure, intraoperative images, and surgical route. There will be plenty of time.

After all, the rabbit's family wouldn't report it to the medical department and cause a dispute over liability...

About twenty minutes later, Fang Ziye looked at the exposed spinal cord, paused briefly, and said his first words after opening the stage: "The spinal cord can be opened."

Wang Ou nodded in agreement with Fang Ziye's argument, but the doubt that had been lingering for so long finally escaped his lips: "Professor Fang, when did you learn spinal cord stenosis?"

"Did you learn it from somewhere?"

What Wang Ou was more concerned about was how Fang Ziye could be so familiar with the surgical procedures for spinal cord surgery.

Fang Ziye should not have undergone spinal cord surgery.

"Professor Wang, you taught me?" Fang Ziye's voice was very calm.

Wang Ou was speechless for a moment, looking at Fang Ziye, her emotions unable to calm down for a long time—

Therefore, after observing his own surgeries a few times, Fang Ziye learned how to perform spinal cord slit surgery.

Therefore, Fang Ziye's talent was so extraordinary.

Of course, this is the truth.

If Fang Ziye's talent isn't good enough, and he still can't learn it after watching it several times, then there's something wrong with Fang Ziye.

Such mediocre talent was insufficient to support Fang Ziye's rise to prominence in the orthopedic field, enabling him to create miracles time and time again...

Wang Ou neither praised him nor pursued the reason further, but instead lowered her head and waited for Fang Ziye to continue clearing the way.

Professor Wang Ou is familiar with all spinal surgeries, but when it comes to procedures in the spinal cord area, she has no prior experience and no reference to draw upon.

Surgery in the spinal cord region worldwide is limited to removing "foreign objects" from inside the spinal cord, such as bullets in other countries or intraspinal tumors that are widespread throughout the world.

However, this surgery was not a lesion removal or foreign body removal procedure.

Fang Ziye then looked at Liao Jia and paused again: "Professor Liao, did you see it clearly?"

"Compared to MRI, this kind of direct local lesion should be more accurate."

Liao Jia's expression was more serious than Wang Ou's.

He created the rabbit spinal cord injury model, which was replicated based on the MRI findings of existing clinical patients.

However, Fang Ziye had never opened the patient's spinal cord before, so Liao Jia did not know the specific extent of the damage inside the patient's spinal cord.

Therefore, the only way to 'replicate' the injury corresponding to the symptoms is to rely on the current theories and mechanisms of spinal cord injury.

Such 'damage' will ultimately differ to some extent from the actual patient, although the difference is not large.

However, when it comes to the type of disease and the surgery, a slight difference can lead to a huge error.

Liao Jia did not engage in mutual flattery, but instead extended an invitation, saying, "However, the current damage was still caused by my own actions."

"It's not clinically replicable. If I have the opportunity, I'd like to see more cases of the spinal cord in real patients!"

Creating animal experimental models, apart from models for basic experimental projects, only requires proper processing.

Animal models relevant to clinical research should ideally be based on the patients themselves!
As with previous damage, Liao Jia can be observed freely in clinical settings.

They can even visit other hospitals to examine the amputated limbs of patients after their injuries, carefully observe them, and then, through certain means, transfer the specific details of the injuries into animals as material for experimental procedures.

However, spinal cord injury is not a destructive injury, and the injury is not as visually apparent as a destructive injury. The injury situation in rabbits can only be guessed and replicated based on theory, and there is still a certain distance from real clinical practice, which needs to be optimized.

"It will open!"

"I will invite Professor Liao to come and see it, but before opening the spinal cord of a real patient, I still need to do a few more animal experiments to become proficient before I can bring it to clinical use."

"I only recently realized something: perhaps the spinal cord area isn't so noble, nor is it something that can't be opened."

"Moreover, after opening it, when we perform microcurrent stimulation with local acupuncture electrodes, the range can be wider, the points can be more precise, and there can be more sites, which can also save more functions."

"Through electrical stimulation of the peripheral nerves in the equina region of rabbits, we can confirm that the course and electrical pathways of the peripheral nerves below the spinal cord are intact, and they have not caused damage to the peripheral nerves as in diabetes..."

The difficulty in developing a treatment for a new disease lies in the fact that sometimes it's hard to know where to begin.

The patient's spinal cord cannot be removed!

Surgeons cannot easily open the patient's spinal cord area.

How can we provide targeted treatment if we can't even see the patient's specific condition?

If the incision is being practiced in animal experiments, the spinal cord area of ​​the rabbit is normal. Even if it is cut off, what use would it be?

Therefore, Liao Jia's ability to replicate clinical diseases on animals became a good breakthrough point.

This allows Fang Ziye to first understand the patient's symptoms, and then, based on those symptoms, to examine the internal condition of the spinal cord by opening the local area, thereby accumulating experience in opening the spinal cord area of ​​rabbits with spinal cord injuries.

Once you have gained experience, you can return to the clinic and optimize the animal testing model. By repeating this process multiple times, a positive feedback loop is formed, and it will not cause unacceptable 'devastating' harm to patients!
In clinical practice, there is a principle called the principle of non-harm, which means that whether it is surgery or drug treatment, it should not cause irreparable harm to the patient.

This principle is the most difficult to control and is the main reason why most clinical research projects are excluded.

Finding a good breakthrough point is key.

“The spinal cord of a living organism and the spinal cord that has atrophied after death are completely different ecosystems!” Liao Jia read through the patient’s spinal cord area, constantly collecting what he considered to be the key parts for later use.

"Brother Liao, the video has been recorded, and you've already watched it for quite some time. After you've watched it, I'm going to perform open-type local microcurrent stimulation!"

"Until a suitable replacement for the spinal cord region is found and a surgical procedure is performed, we cannot arbitrarily remove or replace local areas of the spinal cord."

"At this point, the approach we need to find is to promote the regeneration of local functions, which may require physical or pharmaceutical means."

"My idea is, first, we should make a batch of models for recovery by acupuncture electrodes."

"Second, we will create a batch of animal models of local injection of growth factors or growth factor-like clusters."

"Third, we will create a batch of animal models of local perfusion of neurotrophic drugs to observe the differences among the three!"

"If the effect is good, we will then use it in combination depending on the specific situation!"

Fang Ziye's current spinal cord and nerve treatment skills are only at level 3. What he can do is provide some ideas for the treatment of spinal cord injuries.

To further improve the overall level of treatment, Fang Ziye would need to find a key 'breakthrough point,' such as a major breakthrough in a crucial skill.

Or perhaps one's thinking has stumbled upon a very sensitive point, leading to a significant breakthrough in spinal cord and nerve treatment experience, activating a new level or progress bar!
This requires constant experimentation and reflection.

After all, this panel of one's own cannot be created "out of thin air" at will; otherwise, with so many knowledge points, let alone spinal cord injury.

Even with ALS, Fang Ziye could see right through it...

Breakthroughs in treating one disease lead to the acquisition of more knowledge. This continuous positive feedback loop, even with only a few years of clinical experience, means that few diseases will remain unexplored in clinical practice, unless a newly discovered, undefined disease emerges…

Fang Ziye only explained the general idea; it doesn't mean that all these operations must be completed today.

Today, Fang Ziye will try the microcurrent stimulation technique using acupuncture electrodes after exposing and opening a local area of ​​the spinal cord.

Because the spinal cord area has been opened, Fang Ziye can insert a considerable number of acupuncture electrodes at the same time!

After inserting eight acupuncture electrodes at once, Fang Ziye spent nearly forty minutes fixing them in place: "The spinal cord area is newly opened. Although we can place more acupuncture electrodes, there is only so much space."

"The more needle electrodes you use, the more crowded it becomes, making it difficult to achieve proper fixation."

"Fortunately, it's all done."

After Fang Ziye finished speaking, he turned to look at Song Tingzhen of Dabo Company: "Manager Song, I have a suggestion for you. You could design a special needle electrode to see if it is possible to install multiple steerable needle electrode groups at the same time."

"In this way, it is easier to fix the device, and more microcurrent stimulation nodes can be placed."

"I may not have explained it clearly enough, but its principle is similar to a power bank that can connect to three or more devices at once, which can save a lot of space."

Upon hearing this, Song Tingzhen first frowned, then relaxed, and quickly wrote down Fang Ziye's thoughts in his notebook: "Okay, Professor Fang, I will definitely report your ideas to our research team and engineering team."

"However, it will take quite a while to complete this line of thinking."

Fang Ziye knew it would take time, of course: "It's alright, just wait patiently."

"Adjust the parameters and start continuous microcurrent stimulation. Let's observe the microcurrent stimulation for a while," Fang Ziye instructed the staff in the animal laboratory.

"Professor Fang, should we still use the same parameters as last time?" the 'circulating nurse' asked.

As the circulating nurse specially assigned to Fang Ziye's research team in the laboratory, she meticulously recorded every piece of data, and the laboratory required her to be intimately familiar with every single piece of data.

Otherwise, she could go to another team...

However, Fang Ziye's clinical trial team spends tens or hundreds of thousands of yuan every day in the animal testing laboratory, which is a very considerable income for her.

She naturally had to be very careful and attentive.

This was a special opportunity.

“Yes, as before, 2.8mA, frequency 95!” Fang Ziye replied.

In rabbit experiments, the current level of microcurrent can be higher than that used in clinical trials.

In clinical practice, only a few milliamperes are used to maximize patient safety. However, in animal experiments, the goal is to achieve efficacy and, if effective, to test the safety threshold.
This is the significance of animal testing before clinical trials, and it is also the contribution that laboratory rabbits and mice make to human health.

After the electric current was connected, the rabbit did not experience any particular discomfort.

Naturally, it won't produce a functional effect immediately.

Otherwise, microcurrent stimulation would not be a therapeutic exploration, but a miraculous therapeutic technique, as it requires a certain duration.

You need to run slowly!
After observing for more than ten minutes without much reaction, Fang Ziye said, "Let's keep running here for now, and stop stitching for the time being. Let's run for two or three hours and then see how things go."

"Professor Liao and I will continue to the next area."

"By the way, Mr. Huang, your company seems to have some of the growth factor cluster-related hormones I just mentioned in stock. Could you send some over later?"

"Adjust it a little more!" Fang Ziye looked at Huang Zhongxia from Mindray.

It's not that Mindray is particularly good at producing growth factor cluster hormones, but rather that Mindray has relatively more resources in this area.

"Okay, Professor Fang, as many as you need."

"If you need it urgently, I should be able to arrange for it to be airlifted over in about three hours," Huang Zhongxia replied with great certainty.

They were very cooperative with Fang Ziye's work.

This isn't cooperation; it's Fang Ziye directly feeding him!
If spinal cord injury treatment is successful, what a huge market it would be!
It could even cause a company's market value to skyrocket several times over!
It's a pity that the company can no longer directly invest money in Fang Ziye; otherwise, Mai Rui Company would have wanted to take sole ownership of this project.

But Fang Ziye is not short of research and development funds. In addition, he has brought in a group of old guys, and he himself has a certain influence in the National Natural Science Foundation of China.

Fang Ziye's need for tens of millions of yuan in funding is not difficult at all, given the prior research.

Fang Ziye shook his head: "Then there's no need to rush. It'll be fine if it's usable tomorrow or the day after." After saying this to Liao Jia, Fang Ziye left.

Professor Zhang Quan and Professor Zhang Jianjun from the Department of Neurology immediately followed up. After Fang Ziye had stepped down from the stage, Zhang Quan's question came straight to the point: "Professor Fang, you have to explain how you opened up the spinal cord?"

"What is the purpose of opening it? What is the pathway?"

Fang Ziye said, "Professor Zhang, it's actually very simple. The spinal cord is opened by opening the arachnoid mater and the dura mater. It's done by blunt force manipulation, using a relatively smooth blunt incision."

"The purpose of opening it is to expose the local area in order to obtain a better operating field. Professor Zhang, we still have a long time ahead, let's do a few examples first..."

"Furthermore, I need to organize the relevant theories as well."

As Fang Ziye explained, he walked away, took off his gloves, and stood back in front of the sink to wash his hands: "Professor Zhang, Professor Wang, the spinal cord area can actually be opened; it's not as scary as we thought before."

“The spinal cord may not be a completely reticular structure; even a small breach could have a devastating impact on the patient’s function.”

"From a neurosurgical perspective, it is not impossible to partially remove some of the more important brain structures."

"The spinal cord is somewhat similar to the brain tissue inside the skull. Its main functions are to house, nourish, and protect the nerves!"

"However, whether it has any other functions is currently unknown."

"But one thing we can boldly speculate on is that the outermost medulla may only serve a nutritional and protective function, and has no real function."

"Unlike the intracranial cavity, the cerebral cortex inside the skull is the highest level of nerve and command center."

"And the white and gray matter of the brain are actually conductive structures..."

"The outer membrane of the spinal cord does not have a similar function, which is the most important basic theory that allows us to open it directly."

Upon hearing this, Zhang Quan seemed to be deep in thought.
At Zhongnan Hospital, the neurosurgery department is responsible for spinal cord injuries in the medulla oblongata and above, while the spinal surgery department is responsible for spinal cord injuries in the medulla oblongata and below.

The division of labor is clear.

This research project did not involve intracranial lesions, so no neurosurgical team was involved.

The spinal surgery and neurology teams are now taking over the functions of neurosurgery!
The spinal cord is indeed one of the nerve centers, but it is a relatively low-level center. It can control lower-level nerves and muscles, and it also receives and must receive regulation from the cerebral cortex.

"Let's wait and see. If the spinal cord area can also be opened deeply, then the reproducibility of this clinical trial will be much higher..."

"Professor Fang, there must be some other details as well, right?"

“In the past few days, Wang Ou and I have tried to open the spinal cord directly, but after opening it, we always feel that we have damaged the original structure.”

"Professor Fang, I'll trouble you to explain it to me in detail then."

“If we learn it, Professor Fang, you won’t have to work so hard,” Zhang Quan stated.

He is very eager to do things and works very hard; he's just a young man in his fifties, not yet sixty.

Liao Jia said, "I hope you can learn it soon, Professor Zhang. It's such a different experience to have someone help you and to work without anyone's help."

"Fang Ziye, you should call Shang Kunpeng from Enshi. These people here are too difficult to manage," Liao Jia complained without hesitation.

At this moment, the laboratory staff following Liao Jia all lowered their heads.

Liao Jia had actually completed the replication of the 'spinal cord injury' animal model before the holiday, but it was already past the first ten days of the first lunar month.

They don't need to be original; they just need to learn how to make animal test models, which is still beyond their grasp. Liao Jia has to stay up all night or work on each animal by hand during the day.

Everything we made was for the experiment a week later.

Even if it stops for just one day, the experimental progress a week later will have to be put on hold.

Shang Kunpeng was brought in by Fang Ziye's research group to temporarily replace Liao Jia. After Liao Jia returned, Shang Kunpeng made a special trip to Wuhan to visit Liao Jia.

Now he has returned to the Enshi Sanatorium for further studies.

Upon hearing this, Fang Ziye glanced at the others who were following him and then at Liao Jia: "Brother Liao, you wouldn't happen to have taken a liking to Shang Kunpeng, would you?"

Liao Jia complained, "Don't talk so much. Whether you like him or not, you're already a mature employee. You're way past the age of mentoring someone."

"It's alright, it hasn't been specially stimulated yet, but the technique is decent!"

After saying that, Liao Jia looked at the 'engineers' in charge of animal experiments in the laboratory and said, "Brothers, don't blame me for speaking harshly, I'm just a straightforward person."

"I don't know anything about teaching, and I've never done any teaching before!"

"So, what I said might not be pleasant to hear, but I'm just saying what I mean, so please don't take it too seriously."

“Compared to my previous team, you all seem like people who haven’t really gotten started in animal testing.”

The "engineers" immediately smiled obsequiously: "No, no, Professor Liao, it's just that our abilities are limited and our qualifications are average."

They can be ignorant if they are not involved in animal testing.

But only after entering this industry can they truly appreciate Liao Jia's brilliance. Such a person, not to mention that he has completely conquered the field of animal testing, has even mastered the technology of replicating clinical diseases.

This would allow Liao Jia to act with impunity in the animal testing field, and even academicians and renowned professors would have to suppress their anger and respectfully address him as Professor Liao.

Because, for the time being, it seems that only one company in the whole world possesses such capabilities!

In other specific operations, Liao Jia did not actually reach the pinnacle.

“But Professor Liao, regardless of whether you find someone you trust, we all hope to continue learning how to make these animal models from you!” one person immediately declared.

Since I chose to join the company, my main purpose is to make money.

To make money in the company's laboratory, you need to consider your workload.

Researchers' workload is not related to order volume, but to supply orders.

This is a very high-end technical job. In addition to selling it, you also need to be able to produce it, and the cost of making experimental models is very high.

It is foreseeable that once Fang Ziye starts the research project, the market demand for animal testing models will surge!

Even if the patent rights remain with Liao Jia, they won't earn significantly less than him, since they've also put in the actual work, and are highly replaceable 'high-end research laborers'.
Liao Jia did not refuse: "I hope that more people can learn it, and I don't plan to use this patent to start a business!"

"But don't bring up the matter of buying the patent again. I've already decided to sell it to the 'regular army'."

"If you have the means, you can find out for yourselves."

"But you can use it. I can talk to you about it, and we'll just charge you a token fee."

Since Liao Jia has decided to join the sanatorium, he should naturally strive for results for the sanatorium. Patented achievements are the foundation of the Enshi Sanatorium Research Institute.

We've invested so much money, allocated so many resources, and given you such good benefits, yet you haven't produced anything. So why do you deserve such a special position?
You can be without output for a short period of time, but you can't be without output forever!
Hearing Liao Jia say this, the expressions on the faces of the group turned slightly unpleasant, but they didn't dare to say anything more.

Not being able to secure the patents only means they earn less money and receive fewer rewards, but it's unrealistic to actually take action against what's behind Liao Jia in China.

In China, fundamentally, there is no capital!

The higher your position and the more things you come into contact with, the more you will believe this.

……

Just as Fang Ziye was finishing working on the third animal model, a staff member rushed over excitedly, saying, "Professor Fang, it moved! It moved!"

Upon hearing this, Fang Ziye nodded slightly, showing no surprise whatsoever.

Today's functional reconstruction technique is not only a mature technique, but its proficiency has also reached level 3!
Compared to the previous trial and error of operational knowledge, the difference is at least hundreds or even thousands of times.

Can it remain still?
Liao Jia raised his head thoughtfully, looked into Fang Ziye's calm eyes, and said in a low voice, "Before you started the operation, you said that you suddenly understood something. Was that true?"

Fang Ziye nodded and smiled, "Of course, Brother Liao."

"Can you just say things like that? Do you think I'm starting to follow the example of other team leaders and start making empty promises to encourage others?"

After replying to Liao Jia, Fang Ziye turned back and said, "I understand. Let's leave it for now. Let the microcurrent continue for a while longer, and I'll come over to fix it later."

"Okay, okay, Professor Fang."

"Professor Zhang and Professor Wang also expressed the same opinion. They said that since we have finally made this progress, they dare not make any rash moves."

"The muscles have gradually softened and are no longer as stiff as before!" The staff member reported a more professional and specific observation.

Paralysis caused by spinal cord injury is spastic paralysis.

Unlike flaccid paralysis caused by dysfunction of muscles and peripheral nerves, the muscles of patients with spastic paralysis are usually very stiff, especially in the proximal and distal parts of the affected limb.

This stiffness makes movement difficult for patients. Although their muscles are strong, they are hard to control and often contract involuntarily, leading to spasms.

Spastic paralysis is caused by damage to the superior nerves!
If the superior nerve reconnects with the surrounding neuromuscular system, it will actively suppress this spasm and twitching...

Fang Ziye still hasn't replied!
Ten minutes later, Fang Ziye completed another operation even faster, and then he and Liao Jia stepped off the operating table and walked out of the operating room, standing by the window to rest for a while.

There was a coffee machine in the lab, and Liao Jia very ingratiatingly brought Fang Ziye a cup: "Professor Fang, come on, have some coffee to perk you up."

Seeing Liao Jia's expression, Fang Ziye knew that Liao Jia hadn't finished telling the secret before, and asked, "Judging from your expression, Zheng Gao has a chance, huh?"

Liao Jia said, "Actually, full professor and associate professor are pretty much the same, but researcher and professor sounds much more comfortable."

"After joining the company, I never really expected to get promoted!"

"In the end, we've come to this point again."

"Although it can't compare to many professors who were promoted to full professor in their twenties, it's still a return to the right path."

"I was planning to tell you this later, but you guessed it anyway."

"CAA's attack range and attack power are too strong."

"Even sanatoriums can't withstand its power."

CAA is a foreign journal, but it is an academic journal, and a very high-end one at that.

Liao Jia is also a key contributor to the project, having been involved since its inception.

Now is the harvest season, how can Fang Ziye be the only one to reap the benefits?

Actually, the reason why Lan Tianluo was able to take up the position of chief resident so early was also due to the 'spur' of this research project!
Lan Tianluo's current abilities are still somewhat inferior to those of Fang Ziye when he first became chief resident, so his exceptional performance in clinical practice is even more outrageous.

"Now your sister-in-law will be even more obedient, right?" Fang Ziye asked.

"That's not quite right."

"Whether I get promoted or not, your sister-in-law doesn't have much of an opinion. It's not like I don't earn money or lack ability."

Liao Jia touched his chest and raised his head slightly: "Although I have no experience in conducting scientific research abroad, when it comes to animal testing, I represent China and can defeat even well-known professors in animal testing abroad."

Fang Ziye said, "Of course! Brother Liao, you don't go abroad because you already possess the necessary skills; you just haven't taken that step yet!"

"It's like some people say that college is useless, and they even cite some examples from abroad."

"But those famous people abroad are all geniuses who got into university but didn't go to study."

"Only with the corresponding qualifications and talents can one possibly overtake others through unconventional efforts."

"If you don't have the qualifications and talent, and you still want to take shortcuts, you'll either get a stroke of luck and ride the wave of success, or you'll end up going down the wrong path."

"But no matter what, the path we're on now is still the right one."

"And they're walking quite fast!" Fang Ziye was no longer anxious. After saying that, he slowly sipped his coffee and looked out the window.

Winter has passed, the year-end is over, and spring is not far away.

"You call this not slow? What's the difference between this progress rate and that of a rocket?" Liao Jia's eyes bulged.

"If I didn't know you, I would definitely think you were deliberately showing off." (End of Chapter)