Reborn Tech Scholar

Chapter 454 The study of leukemia
After Yan Ning was shocked, she hesitated!
After she joined the laboratory, she liked the pure scientific research environment here very much. She devoted most of her time to scientific research every year, and the academic exchanges with her colleagues always made her eyes shine. I think the original choice was the wisest choice she made.

Because of that choice, she won a national award, was selected as an academician of the Chinese Academy of Sciences, and successfully won the Nobel Prize in Biology or Medicine.

Letting her leave the laboratory now and go to be the dean of the School of Life Sciences made her a little difficult to choose. After all, she knew the School of Life Sciences, and she would not be able to do scientific research with peace of mind if she went there.

After hesitating for a while, Yan Ning still chose to follow her own heart, shook her head and said, "Principal, I think I prefer to do research and occasionally teach students. The position of dean of the School of Life Sciences is not suitable for me!"

Qin Yuanqing was not disappointed when he heard Yan Ning's answer.

"It's okay, it's right to do what you like!" Qin Yuanqing smiled.

It doesn't matter if Yan Ning doesn't want to take the position, after all, there are still many professors to choose from, and Qin Yuanqing doesn't like to force people to do things he doesn't like.

Qin Yuanqing learned about related research topics in the life laboratory. Up to now, there are as many as 600 researchers in the life laboratory alone, and dozens of related topics.Qin Yuanqing came to the leukemia project to learn about the progress of the leukemia project.

"According to the statistics from the [-] cooperative hospitals, except for a small amount of leukemia caused by virus infection and genetic defects, most of it is induced by chemical pollution!" Song Hua, who is in charge of the project, introduced.

Nowadays, some diseases are showing a trend of rejuvenation, and there have been cases of three or four-year-old children suffering from cancer.For children, leukemia is the most troublesome thing nowadays. A single leukemia will directly bankrupt a well-off family.

The most important reason for children to suffer from leukemia is the decoration and building materials!

After all, children's immune function and physical tolerance are not as good as adults, not to mention they are still in the period of rapid growth and development, so they are more sensitive to environmental pollution!
The most typical decoration carcinogens are formaldehyde, benzene and TVOC!

Although after these years of rectification, the specification requirements for building materials have been much higher than ten years ago, and some indicators are much stricter.However, the building materials for interior decoration are not the same. If there are too many building materials, the carcinogens will have a cumulative effect.

What's more, it is unavoidable that some unscrupulous traders are shoddy, or some people buy low-quality ones in order to save material money for decoration, and the ventilation time is not enough, which leads to the serious situation of children's leukemia. No matter how to control it Can't control it.

Qin Yuanqing paid no less attention to leukemia than cancer and AIDS.According to the latest medical statistics, there are currently at least 400 million leukemia patients in my country, and about 4 new leukemia patients are added every year, 50% of whom are children.

The cost of leukemia treatment is very expensive.Children with acute lymphoblastic leukemia are divided into low-risk, medium-risk and high-risk. Among them, low-risk and medium-risk children will spend at least 2 to 2 years of treatment in 8 to 9 years. If they are high-risk, bone marrow transplantation should be considered. The cost is 30 to 40 yuan!If other expenses are considered, then this cost must be at least doubled!
Huge expenses often make many children with leukemia who are diagnosed choose to give up because the family has no money.However, there is only one consequence of giving up—death!
This also makes, in the past 30 to [-] years, the killer of children, leukemia has been firmly in the top ten list!

Leukemia is already a disease of one person, and the whole family is sad!

Of course, now, with the development of medical treatment and technology, leukemia is no longer an "incurable disease", and it is no longer a "death sentence" before the 70s.In fact, the five-year disease-free survival rate of leukemia has been improved, and the treatment methods are becoming more and more mature.Unfortunately, the biggest obstacle is poverty and disease. Poverty has caused many children with leukemia to stay away from the hospital for treatment, and then die in pain!
Although there are some charitable funds in the society today, as well as Internet fundraising, some babies suffering from leukemia have been treated and their lives have been increased by four or five years, but it is still a drop in the bucket.

To be able to solve leukemia, only by using scientific and technological means to develop specific drugs or vaccines that can cure leukemia, can leukemia be solved once and for all.

Otherwise, just one leukemia would require as much as nearly [-] billion yuan in charity funds every year, and no one can afford it!

Even if it is a country, there is no way!
At present, the treatment of leukemia is difficult to completely cure. The main method is to take targeted drugs to relieve and prolong life.

For example, chronic myelogenous leukemia mainly uses tyrosine kinase inhibitor TKI drugs. This type of drug includes first-generation imatinib, second-generation dasatinib, nilotinib, and bosutinib, and third-generation drugs. Ponatinib, but taking this drug can only maintain a long-term remission state, not a cure.And because these medicines are controlled by overseas pharmaceutical companies, the medicines are very expensive, and the treatment costs are very high.

The main group of chronic lymphocytic leukemia is the elderly, and the degree of malignancy is relatively low. Nucleoside analogs, such as fludarabine, and targeted drugs such as BTK inhibitor ibrutinib and BCL-2 inhibitor Venetoclax are mainly used. , This kind of medicine can only relieve and prolong the patient's survival period, but there is no way to cure it.

As for acute leukemia, although chemotherapy can be cured with a certain probability, chemotherapy can cause great harm to the body, so that leukemia may be cured, but relapse or new malignant diseases may occur in a short time.

Of course, hematopoietic stem cell transplantation can also be used, but because of the magic of the human body, it is naturally repellent to outsiders, so even if it is hematopoietic stem cell transplantation from close relatives, the patient will more or less reject the hematopoietic stem cells from outside the body, which is why the therapeutic effect It is also passable.

Some scientists once proposed that the use of cloning technology to clone the hematopoietic stem cells of the diseased patients would be a perfect solution.

But be aware that this is only in theory.Although cloning technology is not a new technology, so far cloning technology has experienced three development periods: the first period is microbial cloning, that is, using one bacterium to quickly replicate thousands of bacteria that are exactly the same as it, The second stage is biotechnology cloning, such as using genetic genes—DNA cloning; the third stage is animal cloning, that is, a cell is cloned into an animal.The cloned sheep "Dolly" was cloned from the somatic cells of an ewe, using animal cloning technology.

On July 1996, 7, a lamb 'Dolly' with the same genetic structure as the donor was cloned, which caused a sensation all over the world, representing that the cloning technology has reached a new height. It has been more than 5 years, but it is still No biologist dares to pat his chest and say that he has a complete understanding of a kind of life, and a complete understanding of human beings!
Life is life because of complexity!
Cloning technology is based on a very rational state, and once it is used in life, it is often very unsatisfactory. Otherwise, the world has already universalized cloning technology, especially in medical treatment. After all, many diseases can be solved by changing organs solved.

For example, how to make cells grow three-dimensionally to form the structure and shape of organs?Although the development of biomaterials can now prepare simple organ scaffolds, it is still far from usable.For example, how to make different cell types form tight physiological structures and physiological connections?For example, how to solve the influence of foreign substances, such as cell mutations, serum, culture medium, cytokines in the culture process!
Therefore, Qin Yuanqing abandoned the cloning technology from the very beginning, and wanted to break through a series of difficulties in the cloning technology. Qin Yuanqing suspected that even if it took another 50 years or even 100 years, it would not be able to solve it!

"Principal, we are currently trying to see if we can find a certain factor that can alleviate leukemia, or if we can encounter a certain factor that can stimulate hematopoietic stem cells to restore hematopoietic function!" Song Hua said.

Leukemia, also known as blood cancer, is defined from a medical point of view as a type of clonal malignant disease in which hematopoietic stem cells are abnormal. The leukemia cells in the clone lose the ability to further differentiate and mature and stagnate at different stages of cell development.In the bone marrow and other hematopoietic tissues, a large number of leukemia cells proliferate and accumulate and infiltrate other organs and tissues, and at the same time inhibit normal hematopoiesis. The clinical manifestations are anemia, bleeding, infection and infiltration of various organs.

Therefore, there are two research and development directions, one is to relieve the disease through technical means, and the other is to stimulate the rejuvenation of hematopoietic stem cells through technical means!
Qin Yuanqing nodded slightly. Although the project has been going on for a while, there is not much progress so far.

The research on this disease is like this, it is always very slow, maybe ten or 20 years of research may not necessarily make any progress.But we can't give up, because maybe at some point, research in this area will make a historic breakthrough.

At present, the biggest achievement of the laboratory is the research on myocarditis-related diseases and the research on norovirus.These two aspects make Mizuki the world's leading level in these two fields, and many relevant departments of domestic large hospitals will send experts to Mizuki for retreat to learn more theoretical knowledge in these two fields.

Biology and medicine are often closely linked.

This is also the reason why Qin Yuanqing's biological laboratory directly cooperates with [-] major hospitals in research projects, because leaving the hospital, the biological laboratory works hard on its own research, which is nothing more than working behind closed doors, with half the effort.

"I'll take a look at the relevant information to see if I can find relevant clues!" Qin Yuanqing said.

In the entire life laboratory, Qin Yuanqing has the highest authority!He can check the laboratory information at any time. Qin Yuanqing sometimes looks at the research of the subject, and then tries to see if he can advance the research and development progress of the subject.

And he attaches great importance to leukemia. After all, solving this disease can save millions of children, so that millions of children will not have to leave this world just a few years after they came to this world!

(End of this chapter)